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See other articles in PMC that cite the published article. Characterization of the in vivo role of specific viral proteins i. This is a major limitation of our study, since previous studies reported that there is a direct correlation between the amount of cell-associated virus and the rates of breast-feeding transmission in humans 2854 This result is surprising for two reasons. Interventions to reduce mother-to-child transmission of HIV infection:

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Sexual transmission of SIVagm in wild grivet monkeys.

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Non-Human Primate Models in AIDS Research

The mechanisms underlying the restriction of MTIT and virus replication in infant natural hosts for SIV remain poorly understood and are likely to be complex. We designed our study to maximize the opportunity of mother-to-offspring transmission of SIVmnd-1 by inoculating the dames after the delivery and observing the effects of high levels of virus replication in both plasma and milk on the risk of transmission via breast-feeding. Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy. J Acquir Immune Defic Syndr. The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection.

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Of note, late breastfeeding-related transmission events are virtually impossible to separate from early events of horizontal transmission resulting from mock sexual activity that can occur during the first year of life. Identity, dose, and route of virus challenge known. These VL levels observed during the chronic phase of experimental infection are similar to those observed in naturally SIVmndinfected mandrills in the wild This article has been cited by other articles in PMC. This result is surprising for two reasons. There were a further 88 SMs not shown who were classified as indeterminate. Neither fever nor lymphadenopathy was observed.

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